Episodes are composed of several shorts, with each episode consisting of segments following the adventures of Yakko, Wakko and Dot the vast majority of episodes also include a segment featuring fan-favorite characters Pinky and the Brain-two lab mice, one of whom is intelligent and wants to take over the world, while the other is dim-witted and clumsy, often messing up his friend's plans. George, Harold and Mr.Animaniacs continues to focus on the adventures of the Warner siblings, Yakko, Wakko, and Dot-three inseparable, irascible kids-as they embark on further adventures after being absent from television for 22 years, bringing with them the usual wackiness and mayhem they create while adapting to the changes and life of the 21st century.Harry, Ron and Hermione's Adventures allies.Sonic, Red, Kion and Steven Universe's Adventures allies.Simba, Timon, and Pumbaa's Adventures allies.Thomas and Twilight Sparkle's Adventures allies.They will be some of the most recurring allies in George, Harold and Mr.

The Warners will meet Lilo, Stitch and their friends in a future adventure.

In an upcoming Barney adventure, where the Warners will meet the rest of the Backyard Gang, Dot will start an rivalry with Isabella Garcia Shapiro, due to their cuteness, but some time afterwards, they will make up and become friends.

The Warners will guest star in Charlie Brown and Snoopy Get Cheaper by the Dozen and Charlie Brown and Snoopy's Adventures of Robots.

The Warners will meet Barney and friends in Barney's Adventure At Hotel Transylvania.

She's voiced by Tress MacNeille, who does Daisy Duck, Babs Bunny, and others. She sees herself as extremely cute, and is also known for this reminder message: 'Call me Dottie, and you die.' She has a thing for Mel Gibson. He's voiced by Jess Harnell, who does lots of other characters. His voice sounds similar to both former Beatles members Ringo Starr and John Lennon. He's voiced by Rob Paulsen, who does Carl Wheezer and others. According to the 1st issues of the comics books, his middle name is Alvin. He's a really big fan of Michelle Pfieffer. He's known to most as the brains of the three.

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